AMI Distribution and Panacea Shop

04/16/2025

Pharma didn’t ignorethe endocannabinoid system—it’s been trying to hack it for years.

One of the biggest targets over the past couple decades is FAAH (Fatty Acid Amide Hydrolase)—the enzyme that breaks down anandamide (AEA), the best known endocannabinoid
By inhibiting FAAH, you can raise AEA levels, potentially easing pain, anxiety, inflammation, and more—all without the psychoactive effects of THC.

Sounds like an easy win... but the pharma route hasn’t gone smoothly.

After a tragic clinical trial in 2016 caused severe adverse effects (1 death and 5 hospitalizations), enthusiasm for pharma-FAAH inhibitors has faded

Now this study was just published focusing on natural FAAH inhibitors, below I have listed a few that they review...

CBD – Cannabis-derived, weak FAAH inhibitor, slows AEA reuptake
Kaempferol – Found in tea, apples, broccoli
Genistein – Sourced from soybeans
Biochanin A – From red clover
Macamides – Maca root
Curcumin – Turmeric
Eugenol – Clove oil
Myristicin – Nutmeg
Quercetin – Apples, onions, berries

The future of ECS modulation might not come from a lab… but from plants.
These natural compounds could be contributing to the entourage effect well beyond the cannabis plant itself.

Citation:
Nicoara, C., Fezza, F., & Maccarrone, M. (2025). FAAH Modulators from Natural Sources: A Collection of New Potential Drugs. Cells, 14(7), 551.

This link will take you to a page that’s not on LinkedIn

04/16/2025

03/01/2025

Yo

The Illinois Senate is considering a bill to prevent police from searching a vehicle based on the odor of raw or burnt cannabis if the driver is at least 21 years old, WREX 13 reports. The bill would also remove provisions of the state’s adult-use cannabis law that require cannabis to be transport...

01/03/2024

Hey friends!
I have a favor to ask.

Go to my business page
Panacea Third Coast H**p Co
Go to the 3 little dots on the side of page, Hit “invite friends”

Select "𝗜𝗡𝗩𝗜𝗧𝗘 𝗔𝗟𝗟" & done.

You've SUCCESSFULLY supported my business for $0.00 and less than 30 seconds of your time.

Thank YOU for supporting small and local business.

I saw another business owner have this and wanted to copy it. This is an amazing way to help us small business owners! 🤗

12/18/2023

2024 calander is ready for bookings!

$250 back yard rental. $100 deposit

Chairs 2.50 per plus $65 delivery

AUDIO setup $100

Book early and save. Prices will be changing as we upgrade. Also have sponsorships available for 2024, includes banner. Starting at $200 fence line-1000 stage. Package deals available. DM for more interest.

12/18/2023

The paper investigates the role of the endocannabinoid system receptor and ion channel TRPV1 in gut peptide cholecystokinin (CCK) signaling.

Have you heard of the hot new weight-loss drugs Ozempic and Wegovy? Those drugs are based on a short peptide satiety signaling hormone GLP-1. CCK is also a short peptide food intake hormone that binds to specific receptor CCK1R and shares a lot of overlapping mechanisms.

Rachel and team did a deep dive and figured out that while competitive antagonism of TRPV1 failed to alter CCK1R signaling, genetic deletion or pore block of TRPV1 reduced CCK response. This suggests that TRPV1 actually mediates low-affinity effects of CCK-induced G-protein coupled receptor signaling from high-fat diet and satiety signaling.

In plain terms, this shows yet another food-intake physiology system that functions through TRPV1, and provides more data that it is a crucial modulation point for satiety signaling. TRPV1 is directly and indirectly modulated by endocannabinoids and phytocannabinoids alike.

Cannabis has been used for ages to modulate food intake. It is a crucial medicine for some to help eat following chemotherapy. It gives many people the "munchies". Interestingly, many large scale datasets support that cannabis users are actually leaner and less prone to obesity. New research on minor cannabinoids suggests that different molecules have different effects. For instance THCV may actually function to limit food intake.

THCV will be a big splash in 2024.

The gut peptide cholecystokinin (CCK) is released during feeding and promotes satiation by increasing excitation of vagal afferent neurons that innervate the upper gastrointestinal tract. Vagal afferent neurons express CCK1 receptors (CCK1Rs) in the periphery and at central terminals in the nucleus....

12/14/2023

Cannabis contains a variety of terpenes, aromatic compounds responsible for its distinctive scent and potential therapeutic effects. 💮👃🏵️

Their division is based on the number of their carbon structures ranging from mono to sesquiterpenes.

Recent research ilucidated that several different compund groups are involved in the sensoric experience as with fruit, vegetables and other natural sources of volatile aromatic compunds. 🍍🍓🍊🍒🍇

Terpenes however vary from ones that have lower and higher boiling points, dictating attention of the cultivator to achieve best results. 🔥🌡️❄️

Boasting a variety of hundreds these chemichal compunds, each with distinct aromatic profiles and potential effects, it is a mystery to unveil for the scientific and consumer comunity.🤔📈📉

To meniton a few we commonly see in gas chromatography analysis.

The most prevalent terpenes include myrcene, with a boiling point around 167°C, contributing to relaxation and sedation, commonly found in plants like hops, thyme, and lemongrass. 🌿🍃

Pinene, boiling around 155°C, offers anti-inflammatory properties and a pine aroma found in coniferous trees, such as pine trees, as well as in other plants like rosemary, sage, and certain herbs. 🌿🌲

Limonene, boiling at approximately 176°C, provides a citrus scent and may elevate mood and alleviate stress, and prevalent in citrus fruits like lemons, oranges, and grapefruits, being represented many of the cannabis . 🍊🍋

Caryophyllene, with a boiling point of 245°C, exhibits anti-inflammatory characteristics and interacts with the endocannabinoid system, found in black pepper, cloves, and various spices🌶️🍀

At atmospheric pressures and temperatures of course each takes its course at the rate evaporation. ⬇️💨⬆️

Being just a one of many, these terpenes, with varying boiling points, contribute to the effects cannabis has on most consumers, influencing the overall impact of cannabis on individuals based on their unique terpene and cannabinoid profiles.😳😬😴🥴

While it seems this will allways be a center of a spirtied and controversial scietific debate, we cannot deny the diversity and appeal od the chemichal wonders of Cannabis sativa (L.). and will keep exploring this fascinating subject!

12/05/2023

Even though the study used CBD isolate suspened in coconut oil and MCT oil, it was still effective. I’d like to do the opposite. Use the minor compounds isolated, then mixed, and also full spectrum with cannabinoids to determine the best application. So much needs to be studied!

Conclusions

Results from these experiments provide for the first-time evidence that CBD oil has the potential to reduce microbial load and maintain the visual quality of strawberries, which would lengthen their shelf life. Overall, CBD oil seems to be most effective at reducing microbial growth and maintaining quality when the fruit is stored at 10 ℃ than at 1℃. Though results showed that CBD oil has a great potential to be used as an antimicrobial in food applications, there is still a significant amount

06/20/2023

AI news is coming just wait

The first AI DJ debuted on Alpha Media's KBFF Live 95.5FM in Oregon with 'AI Ashley,' inspired by real DJ Ashley Elzinga and using Futuri Media's...

03/24/2023

Again for the people in the back! THC is legal in Texas, the only restricted THC is Delta 9 of which .3% and under by dry weight is legal. Meaning I can make D9 products as long as it stays with in that restriction. Know your rights!

11/25/2022

Come get some!