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02/04/2026
Cannabis has been used for millennia for therapeutic purposes, and there are several anecdotal reports of its consumptio...
01/05/2026

Cannabis has been used for millennia for therapeutic purposes, and there are several anecdotal reports of its consumption as a form of self-medication for the alleviation of psychiatric symptoms (eg, anxiety, depression, and mania). However, epidemiological studies consistently demonstrated that heavy cannabis use is associated with occurrence of psychiatric outcomes, especially in people at risk for psychosis or mood disorders. Hence, evidence supporting cannabis-based interventions for the treatment of mental disorders is equivocal, mainly due to the use of extracts from the whole plant. Cannabis contains various phytocannabinoids, among which ∆ 9 -tetrahydrocannabinol (THC) and cannabidiol (CBD) are the major constituents. Both induce their pharmacological effect by interacting with the endocannabinoid system.

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