2nd On Main

2nd On Main Helping you discover new favorites and serving orangeade at the old Brooks-Byrd Pharmacy in Salem, Va

02/18/2026

I am sorry to announce our store has closed permanently. Thanks to all that supported us! Please check in with our other store Charlotte's Web, which is down the street. You may see a few of our popular items show up there. If there was anything you really want, please let us know and we will try to accommodate your request!

✨SOLD✨
12/30/2025

✨SOLD✨

‼️‼️‼️LAST CHANCE‼️‼️‼️We will be closed for a month after today! We will be open till 5.
12/30/2025

‼️‼️‼️LAST CHANCE‼️‼️‼️

We will be closed for a month after today!
We will be open till 5.

‼️‼️‼️‼️EVERYTHING 30% OFF‼️‼️‼️‼️‼️‼️If not marked with a white paper tag everything is 30% off.
12/29/2025

‼️‼️‼️‼️EVERYTHING 30% OFF‼️‼️‼️‼️‼️‼️

If not marked with a white paper tag everything is 30% off.

‼️‼️‼️‼️30% OFF EVERYTHING‼️‼️‼️‼️Hey everyone! We are having a huge end of year sale! If you’ve had your eye on somethi...
12/28/2025

‼️‼️‼️‼️30% OFF EVERYTHING‼️‼️‼️‼️

Hey everyone! We are having a huge end of year sale! If you’ve had your eye on something this is the time to splurge.

Perfect gifts for a friend this season 🎄 #24153
12/15/2025

Perfect gifts for a friend this season 🎄

#24153

New Christmas and New Year earrings✨🥂
12/11/2025

New Christmas and New Year earrings✨🥂

Hot honey is flavors habanera and chile de arbol 🍯
12/08/2025

Hot honey is flavors habanera and chile de arbol 🍯

Our football crewneck sweatshirt are a huge hit here! Stay festive with red and green this holiday season!✨🎄🎅🏼
12/01/2025

Our football crewneck sweatshirt are a huge hit here! Stay festive with red and green this holiday season!✨🎄🎅🏼

Get someone special a new ornament for their tree this year🎄
11/26/2025

Get someone special a new ornament for their tree this year🎄

Refillable hand soaps! 🧼
11/23/2025

Refillable hand soaps! 🧼

Address

2 East Main Street Salem
Virginia, VA
24153

Telephone

+15404040676

Website

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